Title : Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural.

Pub. Date : 2009 Aug 15

PMID : 19394312






1 Functional Relationships(s)
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1 SMF was a competitive inhibitor of p-aminohippurate uptake by hOAT1 and estrone sulfate uptake by hOAT3 with K(i) values of 225 microM and 1.5mM, respectively. p-Aminohippuric Acid solute carrier family 22 member 6 Homo sapiens