Title : Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.

Pub. Date : 1991 Oct 25

PMID : 1939071






2 Functional Relationships(s)
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1 The inhibitors studied are benzamidine, PPACK, NAPAP, and MD-805, of which the last three are compounds evolved specifically to inhibit thrombin. argatroban coagulation factor II, thrombin Homo sapiens
2 Despite having significantly different chemical structures, NAPAP and MD-805 bind to thrombin in a very similar "inhibitor binding mode" which is not that expected by direct analogy with the binding of substrate. argatroban coagulation factor II, thrombin Homo sapiens