Title : Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function.

Pub. Date : 2009

PMID : 19390592






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Flow cytometric analysis showed that vandetanib treatment significantly increase the intracellular accumulation of doxorubicin and rhodamine 123, substrates of ABCC1 and ABCG2 respectively, in a dose-dependent manner (P<0.05). Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens