Title : Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling.

Pub. Date : 2009 Jun

PMID : 19385062






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Forskolin stimulated angiogenesis of human endothelial cells and in vivo neovascularization, which was accompanied by phosphorylation of CREB, ERK, Akt, and endothelial nitric oxide synthase (eNOS) as well as NO production and VEGF expression. Colforsin cAMP responsive element binding protein 1 Homo sapiens
2 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin cAMP responsive element binding protein 1 Homo sapiens
3 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin cAMP responsive element binding protein 1 Homo sapiens