Pub. Date : 2009 Jul 1
PMID : 19377066
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of the present study was to determine the mechanism by which aspirin acutely increases the activity of NO synthase type 3 (NOS-3), the predominant NOS isoform expressed by platelets, and specifically whether this occurs through an increase in its acetylation. | Aspirin | nitric oxide synthase 3 | Homo sapiens |
| 2 | At all concentrations tested, aspirin increased the activity of NOS-3 from platelets. | Aspirin | nitric oxide synthase 3 | Homo sapiens |
| 3 | Serine phosphorylation of NOS-3 in platelets was decreased, and this was especially marked for serine-1177 phosphorylation, whereas acetylation of NOS-3 was increased, by aspirin incubation. | Aspirin | nitric oxide synthase 3 | Homo sapiens |
| 4 | Serine phosphorylation of NOS-3 in platelets was decreased, and this was especially marked for serine-1177 phosphorylation, whereas acetylation of NOS-3 was increased, by aspirin incubation. | Aspirin | nitric oxide synthase 3 | Homo sapiens |
| 5 | HeLa cells transfected with NOS-3 exhibited an increase in NO biosynthesis following aspirin exposure, and this was associated with acetylation of the enzyme on both serine-765 and serine-771. | Aspirin | nitric oxide synthase 3 | Homo sapiens |
| 6 | CONCLUSION: Aspirin acetylates NOS-3 acutely in platelets, and this causes an increase in its activity as well as a decrease in its phosphorylation. | Aspirin | nitric oxide synthase 3 | Homo sapiens |
| 7 | It is also possible that aspirin indirectly affects NOS-3 activity by acetylating other substrates within the platelet, but this remains to be determined. | Aspirin | nitric oxide synthase 3 | Homo sapiens |