Title : Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system.

Pub. Date : 2009 Jul

PMID : 19376653






4 Functional Relationships(s)
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1 Interestingly, eugenol shares several pharmacological actions with local anesthetics which include inhibition of voltage-gated sodium channel (VGSC) and activation of transient receptor potential vanilloid subtype 1 (TRPV1). Eugenol transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
2 Interestingly, eugenol shares several pharmacological actions with local anesthetics which include inhibition of voltage-gated sodium channel (VGSC) and activation of transient receptor potential vanilloid subtype 1 (TRPV1). Eugenol transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
3 At cellular level, eugenol reversibly inhibited APs and VGSCs in IB(4)+/TRPV1+/Na(v)1.8+ nociceptive TG neurons (Type I-Type III) and IB(4)-/TRPV1-/Na(v)1.8- nociceptive TG neurons (Type IV). Eugenol transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
4 At cellular level, eugenol reversibly inhibited APs and VGSCs in IB(4)+/TRPV1+/Na(v)1.8+ nociceptive TG neurons (Type I-Type III) and IB(4)-/TRPV1-/Na(v)1.8- nociceptive TG neurons (Type IV). Eugenol transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus