Pub. Date : 2009 Aug
PMID : 19374918
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sirolimus is a member of a novel class of immunosuppressant drug that potently suppresses T cell proliferation and expansion by inhibition of the Target of Rapamycin Complex 1 (TORC1) protein kinase. | Sirolimus | CREB regulated transcription coactivator 1 | Homo sapiens |
| 2 | Sirolimus is a member of a novel class of immunosuppressant drug that potently suppresses T cell proliferation and expansion by inhibition of the Target of Rapamycin Complex 1 (TORC1) protein kinase. | Sirolimus | CREB regulated transcription coactivator 1 | Homo sapiens |
| 3 | In polycystic kidney disease, TORC1 activation mediates renal tubular epithelial cell (TEC) proliferation and cyst growth in animals, and Phase III clinical trials are underway to determine the effect of sirolimus in attenuating disease progression in humans. | Sirolimus | CREB regulated transcription coactivator 1 | Homo sapiens |