Title : Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition.

Pub. Date : 2009 Apr

PMID : 19371577






3 Functional Relationships(s)
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1 However, in isolated rat brain capillaries, the COX-2 substrate, arachidonic acid, significantly increased P-glycoprotein transport activity and expression indicating that enhanced substrate flux to COX-2 rather than increased COX-2 expression drives P-glycoprotein up-regulation. Arachidonic Acid prostaglandin-endoperoxide synthase 2 Rattus norvegicus
2 However, in isolated rat brain capillaries, the COX-2 substrate, arachidonic acid, significantly increased P-glycoprotein transport activity and expression indicating that enhanced substrate flux to COX-2 rather than increased COX-2 expression drives P-glycoprotein up-regulation. Arachidonic Acid prostaglandin-endoperoxide synthase 2 Rattus norvegicus
3 However, in isolated rat brain capillaries, the COX-2 substrate, arachidonic acid, significantly increased P-glycoprotein transport activity and expression indicating that enhanced substrate flux to COX-2 rather than increased COX-2 expression drives P-glycoprotein up-regulation. Arachidonic Acid prostaglandin-endoperoxide synthase 2 Rattus norvegicus