Title : Comparative three-month study of the efficacies of metformin and gliclazide in the treatment of NIDD.

Pub. Date : 1991 May

PMID : 1936478






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1 The fasting serum insulin level decreased significantly in the group receiving metformin (26.2 +/- 3.2 mlU/L at entry versus 19.8 +/- 2.3 mlU/L after three months: less than 0.01), and increased in a non-significant way in the group receiving gliclazide (21.6 +/- 3 mlU/L versus 26.5 +/- 5 mlU/L after three months: NS). Metformin insulin Homo sapiens
2 On the other hand, fasting serum insulin levels decreased significantly in patients receiving metformin compared to gliclazide. Metformin insulin Homo sapiens
3 The effect of metformin on serum insulin levels is probably due to its action on insulin resistance and its lack of effect on insulin secretion, in contrast to sulphonylurea hypoglycaemic agents like gliclazide. Metformin insulin Homo sapiens
4 The effect of metformin on serum insulin levels is probably due to its action on insulin resistance and its lack of effect on insulin secretion, in contrast to sulphonylurea hypoglycaemic agents like gliclazide. Metformin insulin Homo sapiens
5 The effect of metformin on serum insulin levels is probably due to its action on insulin resistance and its lack of effect on insulin secretion, in contrast to sulphonylurea hypoglycaemic agents like gliclazide. Metformin insulin Homo sapiens