Title : Differential responses of the backbone and side-chain conformational dynamics in FKBP12 upon binding the transition-state analog FK506: implications for transition-state stabilization and target protein recognition.

Pub. Date : 2009 Mar 20

PMID : 19361439






4 Functional Relationships(s)
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1 Differential responses of the backbone and side-chain conformational dynamics in FKBP12 upon binding the transition-state analog FK506: implications for transition-state stabilization and target protein recognition. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens
2 The macrolide FK506 is a transition-state analog of the catalyzed reaction and displaces FKBP12 from its natural target proteins. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens
3 We compared the conformational exchange dynamics of the backbone and methyl-bearing side chains of FKBP12 in the free and FK506-bound states using NMR relaxation-dispersion experiments. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens
4 In FK506-bound FKBP12, the backbone is confined to a single conformation, while conformational exchange prevails for many methyl groups. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens