Title : Influence of ABCB1 gene polymorphisms and P-glycoprotein activity on cyclosporine pharmacokinetics in peripheral blood mononuclear cells in healthy volunteers.

Pub. Date : 2008 Apr

PMID : 19356075






1 Functional Relationships(s)
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Protein Name
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1 The calcineurin inhibitor cyclosporine is removed from lymphocytes by the drug efflux transporter P-glycoprotein (P-gp) encoded by the ABCB1 gene for which several single nucleotide polymorphisms (SNPs) have been identified. Cyclosporine calcineurin binding protein 1 Homo sapiens