Title : Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP.

Pub. Date : 2009 Jun 15

PMID : 19345731






3 Functional Relationships(s)
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Protein Name
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1 Interestingly, a Wit A-induced increase in ROS levels preceded the up-regulation of CHOP and DR5. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens
2 The involvement of ROS in CHOP-mediated DR5 up-regulation was confirmed by the result that pretreatment with an antioxidant, NAC or catalase, inhibited Wit A-induced up-regulation of both CHOP and DR5. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens
3 The involvement of ROS in CHOP-mediated DR5 up-regulation was confirmed by the result that pretreatment with an antioxidant, NAC or catalase, inhibited Wit A-induced up-regulation of both CHOP and DR5. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens