Pub. Date : 2009 Jun 1
PMID : 19343784
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 2 | Betel-quid use is associated with liver cancer whereas its constituent arecoline is cytotoxic, genotoxic, and induces p53-dependent p21(WAF1) protein expression in Clone-9 cells (rat hepatocytes). | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 3 | Thus, we studied the role of ATM/ATR and PI3K in arecoline-induced p53 and p21(WAF1) protein expression in Clone-9 cells. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 4 | Moreover, arecoline only increased the levels of the p-p53Ser6, p-p53Ser15, and p-p53Ser392 phosphorylated p53 isoforms among the known isoforms. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 5 | We conclude that arecoline activates the ATM/ATR-p53-p21(WAF1) and the PI3K/Akt-mTOR-p53 pathways in Clone-9 cells. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 6 | We conclude that arecoline activates the ATM/ATR-p53-p21(WAF1) and the PI3K/Akt-mTOR-p53 pathways in Clone-9 cells. | Arecoline | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |