Pub. Date : 2009 Apr
PMID : 19343062
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIM: To evaluate the potential drug-drug interactions between bifendate and cyclosporine, a substrate of CYP3A4, in relation to different CYP3A4*18B genotype groups. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | AIM: To evaluate the potential drug-drug interactions between bifendate and cyclosporine, a substrate of CYP3A4, in relation to different CYP3A4*18B genotype groups. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The oral clearance of cyclosporine was altered in all the subjects, with substantial increases by 10.2%+/-4.4% (P=0.004) in CYP3A4*1/*1 subjects, 14.0%+/-12.0% (P=0.048) in CYP3A4*1/*18B subjects, and 32.4%+/-21.7% (P=0.013) in CYP3A4*18B/*18B subjects. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The oral clearance of cyclosporine was altered in all the subjects, with substantial increases by 10.2%+/-4.4% (P=0.004) in CYP3A4*1/*1 subjects, 14.0%+/-12.0% (P=0.048) in CYP3A4*1/*18B subjects, and 32.4%+/-21.7% (P=0.013) in CYP3A4*18B/*18B subjects. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | The oral clearance of cyclosporine was altered in all the subjects, with substantial increases by 10.2%+/-4.4% (P=0.004) in CYP3A4*1/*1 subjects, 14.0%+/-12.0% (P=0.048) in CYP3A4*1/*18B subjects, and 32.4%+/-21.7% (P=0.013) in CYP3A4*18B/*18B subjects. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | CONCLUSION: These results suggest that bifendate decreases the plasma concentration of cyclosporine in a CYP3A4 genotype-dependent manner. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |