Pub. Date : 2009 Jul 7
PMID : 19341783
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic administration of morphine made the expression of RACK1 and CREB mRNA increase in hippocampus and prefrontal cortex. | Morphine | cAMP responsive element binding protein 1 | Mus musculus |
| 2 | The expression of RACK1 and CREB protein was strongly positive in CA1, CA3 and dentate gyrus (DG) of the hippocampus of morphine-treated mice brain, especially the pyramidal neurons in the DG of the hippocampus. | Morphine | cAMP responsive element binding protein 1 | Mus musculus |
| 3 | Using the small interfering RNA technology, we determined that the expression of CREB mRNA was decreased in hippocampus and prefrontal cortex of morphine-treated mice. | Morphine | cAMP responsive element binding protein 1 | Mus musculus |
| 4 | These findings suggest that morphine reward can influence the expression of RACK1 in mouse hippocampus and prefrontal cortex through regulating CREB transcription. | Morphine | cAMP responsive element binding protein 1 | Mus musculus |