Title : NMDA receptors mediate an early up-regulation of brain-derived neurotrophic factor expression in substantia nigra in a rat model of presymptomatic Parkinson's disease.

Pub. Date : 2009 Aug 1

PMID : 19326433






3 Functional Relationships(s)
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1 The pan-BDNF and exon II-BDNF transcript increases were completely abolished by the prior systemic administration of MK-801, a selective antagonist of NMDA receptors. Dizocilpine Maleate brain-derived neurotrophic factor Rattus norvegicus
2 The pan-BDNF and exon II-BDNF transcript increases were completely abolished by the prior systemic administration of MK-801, a selective antagonist of NMDA receptors. Dizocilpine Maleate brain-derived neurotrophic factor Rattus norvegicus
3 MK-801 also blocked the increase in BDNF-IR cells in SN observed 7 days after unilateral 6-OHDA intrastriatal injections. Dizocilpine Maleate brain-derived neurotrophic factor Rattus norvegicus