Pub. Date : 2009 Jul
PMID : 19324859
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 2 | CYP1B1 mRNA was strongly and dose dependently induced by TCDD. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 3 | CYP1B1 protein was detected only after TCDD treatment of the human nonpigmented ciliary epithelial cells. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 4 | CYP1B1 promoter was activated by TCDD. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 5 | CONCLUSIONS: TCDD potently induces CYP1B1 mRNA in human nonpigmented ciliary epithelial cells, suggesting the involvement of an AHR-mediated pathway in the regulation of ciliary CYP1B1 expression. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 6 | CONCLUSIONS: TCDD potently induces CYP1B1 mRNA in human nonpigmented ciliary epithelial cells, suggesting the involvement of an AHR-mediated pathway in the regulation of ciliary CYP1B1 expression. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |