Title : Rational biosynthetic engineering for optimization of geldanamycin analogues.

Pub. Date : 2009 May 4

PMID : 19308924






1 Functional Relationships(s)
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1 A 15-hydroxyl-17-demethoxy non-quinone analogue, DHQ3, exhibited stronger inhibition of Hsp90 ATPase activity (4.6-fold) than geldanamycin. quinone heat shock protein 90 alpha family class A member 1 Homo sapiens