Title : Improved bioavailability of darunavir by use of kappa-carrageenan versus microcrystalline cellulose as pelletisation aid.

Pub. Date : 2009 Aug

PMID : 19303929






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1 Improved bioavailability of darunavir by use of kappa-carrageenan versus microcrystalline cellulose as pelletisation aid. Darunavir activation induced cytidine deaminase Canis lupus familiaris
2 The aim of this study was to produce pellet formulations containing a high drug load (80%) of the poorly soluble HIV-protease inhibitor darunavir, using wet extrusion/spheronization with kappa-carrageenan or microcrystalline cellulose (MCC) as pelletization aid. Darunavir activation induced cytidine deaminase Canis lupus familiaris