Title : Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection.

Pub. Date : 2009 Jun

PMID : 19299527






1 Functional Relationships(s)
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1 Positive selection on the human CYP3A4 may have been triggered by an increased load of dietary steroids, which led to a novel defense mechanism against cholestasis. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens