Pub. Date : 2009
PMID : 19295242
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aspirin-induced COX-2 overexpression in monocytes of aspirin-intolerant patients. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | Aspirin-induced COX-2 overexpression in monocytes of aspirin-intolerant patients. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | BACKGROUND: We hypothesize that alternate regulation of cyclooxygenase-2 (COX-2) may predispose patients to aspirin-induced exacerbations.Therefore, we want to examine the dynamics of COX-2 up-regulation in whole blood monocytes in the presence and absence of aspirin. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | BACKGROUND: We hypothesize that alternate regulation of cyclooxygenase-2 (COX-2) may predispose patients to aspirin-induced exacerbations.Therefore, we want to examine the dynamics of COX-2 up-regulation in whole blood monocytes in the presence and absence of aspirin. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | BACKGROUND: We hypothesize that alternate regulation of cyclooxygenase-2 (COX-2) may predispose patients to aspirin-induced exacerbations.Therefore, we want to examine the dynamics of COX-2 up-regulation in whole blood monocytes in the presence and absence of aspirin. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | BACKGROUND: We hypothesize that alternate regulation of cyclooxygenase-2 (COX-2) may predispose patients to aspirin-induced exacerbations.Therefore, we want to examine the dynamics of COX-2 up-regulation in whole blood monocytes in the presence and absence of aspirin. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 7 | BACKGROUND: We hypothesize that alternate regulation of cyclooxygenase-2 (COX-2) may predispose patients to aspirin-induced exacerbations.Therefore, we want to examine the dynamics of COX-2 up-regulation in whole blood monocytes in the presence and absence of aspirin. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 8 | RESULTS: We found significantly higher COX-2 expression levels after stimulation with LPS and aspirin (mean 78.8, range 44.9-92.3; p = 0.0002) in comparison to LPS alone (mean 65.9%, range 33.6-82.6) in AI patients. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 9 | CONCLUSIONS: The main finding of this study is that COX-2 appears to be differentially regulated in aspirin-sensitive patients. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 10 | What is really new is the observation that aspirin and LPS increase COX-2 expression on blood monocytes of AI asthmatics, a finding in contrast with the lack of an effect of the same stimuli on COX-2 expression on monocytes from healthy subjects. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |