Pub. Date : 2009 Jul 1
PMID : 19291793
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pml and TAp73 interacting at nuclear body mediate imatinib-induced p53-independent apoptosis of chronic myeloid leukemia cells. | Imatinib Mesylate | tumor protein p53 | Homo sapiens |
| 2 | As reported previously, p53(wild) CML was more resistant to imatinib than that lacking p53. | Imatinib Mesylate | tumor protein p53 | Homo sapiens |
| 3 | Here, we searched for an imatinib-induced p53 independent proapoptotic mechanism. | Imatinib Mesylate | tumor protein p53 | Homo sapiens |
| 4 | We found imatinib up-regulated phosphorylation of p38 mitogen-activated protein kinase (MAPK), checkpoint kinase 2 (chk2) and transactivation-competent (TA) p73; expression of pml and bax; formation of PML-nuclear body (NB); and co-localization of TAp73/PML-NB in p53-nonfunctioning K562 and p53(mutant) Meg-01 CML cells, but not in BCR-ABL(-) HL60 cells. | Imatinib Mesylate | tumor protein p53 | Homo sapiens |
| 5 | We found imatinib up-regulated phosphorylation of p38 mitogen-activated protein kinase (MAPK), checkpoint kinase 2 (chk2) and transactivation-competent (TA) p73; expression of pml and bax; formation of PML-nuclear body (NB); and co-localization of TAp73/PML-NB in p53-nonfunctioning K562 and p53(mutant) Meg-01 CML cells, but not in BCR-ABL(-) HL60 cells. | Imatinib Mesylate | tumor protein p53 | Homo sapiens |
| 6 | The imatinib-induced co-localization was also found in primary CML cells from 3 of 6 patients, including 2 with p53(mutant) and one with p53(wild). | Imatinib Mesylate | tumor protein p53 | Homo sapiens |
| 7 | The imatinib-induced co-localization was also found in primary CML cells from 3 of 6 patients, including 2 with p53(mutant) and one with p53(wild). | Imatinib Mesylate | tumor protein p53 | Homo sapiens |
| 8 | A novel p53-independent proapoptotic mechanism using p38 MAPK /pml/TAp73 axis with a step processing at PML-NB and probably with chk2 and bax being involved is hereby evident in some imatinib-treated CML cells. | Imatinib Mesylate | tumor protein p53 | Homo sapiens |