Title : Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.

Pub. Date : 2009 Dec

PMID : 19286977






1 Functional Relationships(s)
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1 The inhibitory concentration causing a 50% decrease in aSMA for CDDO was 20-fold lower than the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15 d-PGJ(2)), and 400-fold lower than the synthetic ligand, rosiglitazone. 15-deoxy-delta peroxisome proliferator activated receptor gamma Homo sapiens