Title : Flow-induced dilation is mediated by Akt-dependent activation of endothelial nitric oxide synthase-derived hydrogen peroxide in mouse cerebral arteries.

Pub. Date : 2009 May

PMID : 19286591






3 Functional Relationships(s)
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1 Flow-induced dilation is mediated by Akt-dependent activation of endothelial nitric oxide synthase-derived hydrogen peroxide in mouse cerebral arteries. Hydrogen Peroxide thymoma viral proto-oncogene 1 Mus musculus
2 Akt inhibition with triciribine prevented FMD and H(2)O(2)-associated rise in fluorescence (3+/-1% and +23+/-4% a.u., respectively; P<0.05), but not acetylcholine-induced dilation. Hydrogen Peroxide thymoma viral proto-oncogene 1 Mus musculus
3 CONCLUSIONS: In healthy C57Bl/6 mouse cerebral arteries, Akt-dependent activation of endothelial nitric oxide synthase-derived H(2)O(2) mediates flow-dependent dilation. Hydrogen Peroxide thymoma viral proto-oncogene 1 Mus musculus