Title : Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.

Pub. Date : 2009 Jun 2

PMID : 19284778






1 Functional Relationships(s)
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1 For one such hit class, defined by a central aminobenzylpiperidine (ABP) moiety, X-ray crystal structures of BACE mutant-disulfide conjugates revealed that the fragment bound by engaging both catalytic aspartates with hydrogen bonds. Hydrogen beta-secretase 1 Homo sapiens