Pub. Date : 2009 Jun 1
PMID : 19279159
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. | polyglutamine | androgen receptor | Mus musculus |
| 2 | To clarify the importance of the nucleus in SBMA, we genetically manipulated the nuclear localization signal of the polyglutamine-expanded AR. | polyglutamine | androgen receptor | Mus musculus |
| 3 | While we found that nuclear localization of polyglutamine-expanded AR is required for SBMA, we also discovered, using cell models of SBMA, that it is insufficient for both aggregation and toxicity and requires androgens for these disease features. | polyglutamine | androgen receptor | Mus musculus |
| 4 | Thus, our studies firmly establish that polyglutamine-expanded AR must reside within nuclei in the presence of its ligand to cause SBMA. | polyglutamine | androgen receptor | Mus musculus |