Pub. Date : 2008
PMID : 19276532
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation. | Glutathione | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Genetic inhibition of B-Raf, the upstream of ERK, also resulted in increased GCL activity and GSH level. | Glutathione | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Therefore, the findings in the present study suggest that inhibition of B-Raf/MEK/ERK pathway might be a promising physiological approach to up-regulate GCL activity and GSH. | Glutathione | mitogen-activated protein kinase 1 | Homo sapiens |