Title : Potential role of cytochrome P450-1B1 in the metabolic activation of 4-aminobiphenyl in humans.

Pub. Date : 2009 Aug

PMID : 19274671






2 Functional Relationships(s)
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1 Indeed higher levels of 4-ABP-Hb adducts were observed in homo- and heterozygous carriers of the CYP1B1 (432)Leu as compared to the double CYP1B1 (432)Val genotype. Leucine cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 Noteworthy, a saturation effect was observed for 4-ABP-Hb adduct formation at high smoking doses limited to carriers of the CYP1B1 (432)Leu allele. Leucine cytochrome P450 family 1 subfamily B member 1 Homo sapiens