Pub. Date : 2009 Apr
PMID : 19270172
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling. | dipalmitoylphosphatidylserine | brinker | Drosophila melanogaster |
| 2 | Much of the regulation of transcriptional output by Dpp is mediated through repression of the transcriptional repressor Brinker (Brk), and thus through the activation of target genes. | dipalmitoylphosphatidylserine | brinker | Drosophila melanogaster |
| 3 | Much of the regulation of transcriptional output by Dpp is mediated through repression of the transcriptional repressor Brinker (Brk), and thus through the activation of target genes. | dipalmitoylphosphatidylserine | brinker | Drosophila melanogaster |
| 4 | At the molecular level, reduced Dpp signaling results in Brk upregulation that triggers apoptosis through activation of the JNK pathway. | dipalmitoylphosphatidylserine | brinker | Drosophila melanogaster |
| 5 | Here we show that the transcriptional co-regulator dNAB is a Dpp target in the developing wing that interacts with Brk to eliminate cells with reduced Dpp signaling through the JNK pathway. | dipalmitoylphosphatidylserine | brinker | Drosophila melanogaster |
| 6 | Here we show that the transcriptional co-regulator dNAB is a Dpp target in the developing wing that interacts with Brk to eliminate cells with reduced Dpp signaling through the JNK pathway. | dipalmitoylphosphatidylserine | brinker | Drosophila melanogaster |
| 7 | We further show that both dNAB and Brk are required for cell elimination induced by differential dMyc expression, a process that depends on reduced Dpp transduction in outcompeted cells. | dipalmitoylphosphatidylserine | brinker | Drosophila melanogaster |
| 8 | We propose a novel mechanism whereby the morphogen Dpp regulates the responsiveness to its own survival signal by inversely controlling the expression of a repressor, Brk, and its co-repressor, dNAB. | dipalmitoylphosphatidylserine | brinker | Drosophila melanogaster |