Title : Role of cAMP-dependent protein kinase in the regulation of platelet procoagulant activity.

Pub. Date : 2009 May 1

PMID : 19268649






2 Functional Relationships(s)
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1 Pretreatment of platelets with cAMP-elevating agent, forskolin, abolished thrombin plus collagen-induced MP formation and PS exposure, and obviously decreased calcium ionophore-evoked MP shedding. Colforsin coagulation factor II, thrombin Homo sapiens
2 PKA inhibitor-induced MP formation was dose-dependently inhibited by calpain inhibitor MDL28170, and forskolin abrogated thrombin plus collagen-induced calpain activation. Colforsin coagulation factor II, thrombin Homo sapiens