Title : [The effect of pH and reversible inhibitors on decarbamylation of acetylcholinesterase].

Pub. Date : 1991 May-Jun

PMID : 1926583






1 Functional Relationships(s)
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1 Tacrine, a non-competitive inhibitor in concentrations below the inhibition constant (Ki = 1.4 x 10(-7) M) exerts the most intensive effect on the decarbamylation rate of methyl- and dimethylcarbamylated acetylcholinesterase of the mouse brain, while ambenonium and galanthamine in concentrations much (tens times) exceeding their Ki (3.1 x 10(-10) M and 4.4 x 10(-7) M, respectively) provide a decrease of the decarbamylation rate. Galantamine acetylcholinesterase Mus musculus