Title : Role of the perforin/granzyme cell death pathway in D-Gal/LPS-induced inflammatory liver injury.

Pub. Date : 2009 May

PMID : 19264954






1 Functional Relationships(s)
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1 Although it is well known that hepatocellular apoptosis in D-galactosamine/lipopolysaccharide (D-Gal/LPS)-associated liver failure is mediated by TNF-alpha-dependent Fas/FasL cytotoxicity, there is no information on the role of perforin-mediated mechanisms in vivo. Galactosamine tumor necrosis factor Mus musculus