Title : Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses.

Pub. Date : 2009 May 1

PMID : 19254950






2 Functional Relationships(s)
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1 In permanently transfected cells with approximate 2-fold overexpression of GPx-1, we found that intracellular accumulation of oxidants in response to exogenous hydrogen peroxide was diminished, as was epidermal growth factor receptor (EGFR)-mediated Akt activation in response to hydrogen peroxide or EGF stimulation. Hydrogen Peroxide epidermal growth factor receptor Homo sapiens
2 In permanently transfected cells with approximate 2-fold overexpression of GPx-1, we found that intracellular accumulation of oxidants in response to exogenous hydrogen peroxide was diminished, as was epidermal growth factor receptor (EGFR)-mediated Akt activation in response to hydrogen peroxide or EGF stimulation. Hydrogen Peroxide epidermal growth factor receptor Homo sapiens