Title : The effects of aerosolized STAT1 antisense oligodeoxynucleotides on rat pulmonary fibrosis.

Pub. Date : 2009 Feb

PMID : 19254480






1 Functional Relationships(s)
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1 Previous study showed that aerosolized signal transducer and activator of transcription-1 (STAT1) antisense oligodeoxynucleotide (ASON) inhibited the expression of STAT1 and ICAM-1 mRNA and protein in alveolar macrophages (AMs) and decreased the concentrations of TGF-beta, PDGF and TNF-alpha in bronchioalveolar lavage fluid (BALF) in bleomycin (BLM)-induced rat pulmonary fibrosis. Bleomycin intercellular adhesion molecule 1 Rattus norvegicus