Pub. Date : 2009 Jun
PMID : 19251817
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The differences in the K(D) values for CYP2A6 versus CYP2A13 ranged from 74-fold for 2"-methoxyacetophenone to 1.1-fold for coumarin, with CYP2A13 demonstrating the higher affinity. | coumarin | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |
| 2 | The differences in the K(D) values for CYP2A6 versus CYP2A13 ranged from 74-fold for 2"-methoxyacetophenone to 1.1-fold for coumarin, with CYP2A13 demonstrating the higher affinity. | coumarin | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |
| 3 | Inclusion of four CYP2A13 amino acids resulted in a CYP2A6 mutant protein (I208S/I300F/G301A/S369G) with binding affinities for MAP and PEITC much more similar to those observed for CYP2A13 than to those for CYP2A6 without altering coumarin binding. | coumarin | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |