Pub. Date : 2009 May
PMID : 19249327
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Armodafinil promotes wakefulness and activates Fos in rat brain. | Modafinil | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | Modafinil increases waking and labeling of Fos, a marker of neuronal activation. | Modafinil | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | Armodafinil had differential effects in increasing neuronal Fos immunolabeling 2 h after administration. | Modafinil | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | Armodafinil at 100 mg/kg increased numbers of Fos-labeled neurons in striatum and anterior cingulate cortex, without affecting nucleus accumbens. | Modafinil | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 5 | Armodafinil at 30 mg/kg only increased numbers of light Fos-labeled neurons in the anterior cingulate cortex. | Modafinil | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 6 | In brainstem arousal centers, 100 mg/kg armodafinil increased numbers of Fos-labeled neurons in the tuberomammillary nucleus, pedunculopontine tegmentum, laterodorsal tegmentum, locus coeruleus, and dorsal raphe nucleus. | Modafinil | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 7 | Fos activation of these brainstem arousal centers, as well as of the cortex and striatum, is consistent with the observed arousal effects of armodafinil. | Modafinil | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |