Title : Activation of human neutrophil Mac-1 by anion substitution.

Pub. Date : 2009 May-Jun

PMID : 19246218






2 Functional Relationships(s)
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1 Substituting the medium chloride with glucuronate or glutamate causes a rapid, 10 to 30-fold, increase in the binding of the monoclonal antibody, CBRM1/5, which recognizes the high-affinity conformation of the Mac-1 integrin. Glucuronic Acid integrin subunit alpha M Homo sapiens
2 The percentage of Mac-1 in the high affinity state approaches 100% in glutamate and 50% in glucuronate, a far greater response than what is observed after stimulation with fMLP. Glucuronic Acid integrin subunit alpha M Homo sapiens