Title : Maturation of coordinated immediate early gene expression by cocaine during adolescence.

Pub. Date : 2009 Apr 21

PMID : 19245875






2 Functional Relationships(s)
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1 The purpose of the present study was to correlate cocaine-induced locomotor activity with neuronal activation in subregions of the striatum and cortex by acute cocaine in young adolescent (postnatal (PN) 28) and adult (PN 65) male rats by measuring the induction of the plasticity-associated immediate early genes (IEGs) c-fos and zif268 using in situ hybridization. Cocaine early growth response 1 Rattus norvegicus
2 Low dose cocaine induced more locomotor activity and striatal c-fos expression in adolescents than adults whereas high dose cocaine induced more locomotor activity, striatal c-fos, and striatal zif268 expression in adults. Cocaine early growth response 1 Rattus norvegicus