Pub. Date : 2009 May
PMID : 19244331
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 2 | Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 3 | Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 4 | Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 5 | Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 6 | Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 7 | Taken together, these results indicate that RBV uptake is restricted primarily to ENT1 in the cell lines examined. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 8 | Interestingly, some RBV-resistant cell lines may compensate for reduced ENT1-mediated nucleoside uptake by increasing the activity of an alternative nucleoside transporter, ENT2. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |