Pub. Date : 2009 Jul
PMID : 19219625
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Rattus norvegicus |
| 2 | Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Rattus norvegicus |
| 3 | Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Rattus norvegicus |
| 4 | Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the pathogenesis of hepatic steatosis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Rattus norvegicus |
| 5 | To conclude, chronic ethanol consumption impairs PC generation via the PEMT pathway resulting in diminished VLDL secretion which contributes to the development of hepatic steatosis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Rattus norvegicus |
| 6 | By increasing PEMT-mediated PC generation, betaine results in increased fat export from the liver and attenuates the development of alcoholic fatty liver. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Rattus norvegicus |