Pub. Date : 2009 May 15
PMID : 19218193
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reduction of uric acid levels using the inhibitor of uric acid synthesis allopurinol or uricase leads to a decrease in BLM-induced IL-1beta production, lung inflammation, repair, and fibrosis. | Uric Acid | interleukin 1 beta | Mus musculus |
| 2 | Reduction of uric acid levels using the inhibitor of uric acid synthesis allopurinol or uricase leads to a decrease in BLM-induced IL-1beta production, lung inflammation, repair, and fibrosis. | Uric Acid | interleukin 1 beta | Mus musculus |
| 3 | CONCLUSIONS: Uric acid released from injured cells constitutes a major endogenous danger signal that activates the NALP3 inflammasome, leading to IL-1beta production. | Uric Acid | interleukin 1 beta | Mus musculus |
| 4 | Reducing uric acid tissue levels represents a novel therapeutic approach to control IL-1beta production and chronic inflammatory lung pathology. | Uric Acid | interleukin 1 beta | Mus musculus |