Title : Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides.

Pub. Date : 2009 Mar

PMID : 19210614






1 Functional Relationships(s)
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1 Here we analysed the lipid profile of lag1Delta lac1Delta mutants lacking acyl-CoA-dependent ceramide synthesis, which require the reverse ceramidase activity of overexpressed Ydc1p for sphingolipid biosynthesis and viability. Acyl Coenzyme A alkaline dihydroceramidase Saccharomyces cerevisiae S288C