Title : A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes.

Pub. Date : 2009 May

PMID : 19204080






1 Functional Relationships(s)
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1 6-MNA activity correlated strongly with both CYP1A2-mediated phenacetin O-deethylation activity and CYP1A2 protein content (r = 0.85 and 0.74, respectively; p < 0.0001 for both). Phenacetin cytochrome P450 family 1 subfamily A member 2 Homo sapiens