Title : Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C).

Pub. Date : 2009 Feb 15

PMID : 19201856






2 Functional Relationships(s)
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1 We show herein that induction of lymphodepletion by a single 4 mg cyclophosphamide (CTX) treatment induces a marked expansion of immature dendritic cells (DCs) in the peripheral blood on days 8-16 post-CTX (termed restoration phase). Cyclophosphamide cytochrome P450 family 27 subfamily A member 1 Homo sapiens
2 We show herein that induction of lymphodepletion by a single 4 mg cyclophosphamide (CTX) treatment induces a marked expansion of immature dendritic cells (DCs) in the peripheral blood on days 8-16 post-CTX (termed restoration phase). Cyclophosphamide cytochrome P450 family 27 subfamily A member 1 Homo sapiens