Pub. Date : 2009 May
PMID : 19197988
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To understand APN1-dependent mtDNA repair processes we studied the formation and repair of mtDNA lesions in cells exposed to methyl methanesulfonate (MMS). | Methyl Methanesulfonate | DNA-(apurinic or apyrimidinic site) lyase APN1 | Saccharomyces cerevisiae S288C |
| 2 | To understand APN1-dependent mtDNA repair processes we studied the formation and repair of mtDNA lesions in cells exposed to methyl methanesulfonate (MMS). | Methyl Methanesulfonate | DNA-(apurinic or apyrimidinic site) lyase APN1 | Saccharomyces cerevisiae S288C |
| 3 | We show that MMS induces mtDNA damage in a dose-dependent fashion and that deletion of the APN1 gene enhances the susceptibility of mtDNA to MMS. | Methyl Methanesulfonate | DNA-(apurinic or apyrimidinic site) lyase APN1 | Saccharomyces cerevisiae S288C |