Pub. Date : 2009 Feb 24
PMID : 19196973
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | For the most prevalent fungal pathogen of humans, Candida albicans, Hsp90 mediates resistance to azoles, which inhibit ergosterol biosynthesis and are the most widely deployed antifungals in the clinic. | Azoles | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | Combination therapy with Hsp90 inhibitors that are well tolerated in humans and an azole rescued larvae from lethal C. albicans infections. | Azoles | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | In a murine model of disseminated candidiasis, genetic compromise of C. albicans HSP90 expression enhanced the therapeutic efficacy of an azole. | Azoles | heat shock protein 90 alpha family class A member 1 | Homo sapiens |