Title : Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism.

Pub. Date : 2009 Apr 30

PMID : 19190243






1 Functional Relationships(s)
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1 Therefore, therapeutic combinations of Nutlin-3 + gamma-secretase inhibitors might potentiate the cytotoxicity of Nutlin-3 in p53(wild-type) leukemic cells. nutlin 3 tumor protein p53 Homo sapiens