Title : Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention.

Pub. Date : 2009 May

PMID : 19188864






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 RESULTS: Halofuginone prevented cerulein-dependent increase in collagen synthesis, collagen cross-linking enzyme P4Hbeta, Cygb/STAP, and tissue inhibitors of metalloproteinase 2. halofuginone sequestosome 1 Mus musculus
2 In culture, halofuginone inhibited pancreatic stellate cell (PSC) proliferation and TGFbeta-dependent increase in Cygb/STAP and transgelin synthesis and metalloproteinase 2 activity. halofuginone sequestosome 1 Mus musculus