Title : UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.

Pub. Date : 2009 Feb

PMID : 19187776






1 Functional Relationships(s)
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1 In wild-type mice, high-fat diet increased norepinephrine-induced thermogenesis; i.e., diet-induced thermogenesis was observed, but no such effect was observed in UCP1-ablated mice, demonstrating that diet-induced thermogenesis fully emanates from UCP1 activity. Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus