Pub. Date : 2009 Feb
PMID : 19187092
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice. | Levodopa | mitogen-activated protein kinase 1 | Mus musculus |
| 2 | In the dopamine-depleted striatum, extracellular signal-regulated kinase (ERK) signaling is implicated in the development of L-DOPA-induced dyskinesia. | Levodopa | mitogen-activated protein kinase 1 | Mus musculus |
| 3 | In the dopamine-depleted striatum, extracellular signal-regulated kinase (ERK) signaling is implicated in the development of L-DOPA-induced dyskinesia. | Levodopa | mitogen-activated protein kinase 1 | Mus musculus |
| 4 | To gain insights on its role in this disorder, we examined the effects of L-DOPA on the state of phosphorylation of ERK and downstream target proteins in striatopallidal and striatonigral medium spiny neurons (MSNs). | Levodopa | mitogen-activated protein kinase 1 | Mus musculus |
| 5 | In 6-hydroxydopamine-lesioned Drd2-EGFP mice, L-DOPA increased the phosphorylation of ERK, mitogen- and stress-activated kinase 1 and histone H3, selectively in EGFP-negative MSNs. | Levodopa | mitogen-activated protein kinase 1 | Mus musculus |
| 6 | The same pattern of activation of ERK signaling was observed in dyskinetic mice, after repeated administration of L-DOPA. | Levodopa | mitogen-activated protein kinase 1 | Mus musculus |
| 7 | Our results demonstrate that in the dopamine-depleted striatum, L-DOPA activates ERK signaling specifically in striatonigral MSNs. | Levodopa | mitogen-activated protein kinase 1 | Mus musculus |